{\displaystyle {\ce {LP}}} [clarification needed] Definition noun (1) A mathematical constant that describes the tendency of a large molecule to dissociate reversibly into smaller components. The base dissociation constant can … “Dissociation constant.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/dissociation%20constant. {\displaystyle {{\ce {[L]_{bound}}}}} [citation needed] It is useful as a quick description of the binding of a substance, in the same way that EC50 and IC50 describe the biological activities of substances. A simplified mechanism can be formulated if the affinity of all binding sites can be considered independent of the number of ligands bound to the macromolecule. The major characteristic of all dissociative phenomena involves a detachment from reality, rather than a loss of reality as in psychosis. Before using our website, please read our Privacy Policy. 'Nip it in the butt' or 'Nip it in the bud'. K equilibrium constant - (chemistry) the ratio of concentrations when equilibrium is reached in a reversible reaction (when the rate of the forward reaction equals the rate of the reverse reaction) i This simple interpretation does not apply for higher values of x or y. (II) Association/dissociation of Bb-cC (association constant [k.sub.2]; where, R is the gas constant, T is the absolute temperature and K is the same as the solubility-product constant for water-insoluble compound or the, Frontal affinity chromatography (FAC) thus established allowed us by a simple experiment to determine the most important parameter of specific interaction, that is, an equilibrium constant (, where, [[cAMP].sub.C1] and [[cAMP].sub.C2] are the cAMP concentrations in compartments 1 and 2, A[C.sub.basal] is basal adenylyl cyclase activity (cAMP synthesis), [V.sub.maX] is the maximal rate of cAMP hydrolysis by PDE, [K.sub.m1] is the Michaelis constant for PDE activity, [I] is the concentration of PDE inhibitor, KI is the inhibitor, 4'OH-PCB 12 had the highest-affinity binding in this study, and it exhibited a significantly lower, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Cellular and Biophysical Pipeline for the Screening of Peroxisome Proliferator-Activated Receptor Beta/Delta Agonists: Avoiding False Positives, Kinetic tools for the identification of ligand--receptor interaction mechanisms, Inhibition of [alpha]-Amylases by Condensed and Hydrolysable Tannins: Focus on Kinetics and Hypoglycemic Actions, Finding Solvable Units of Variables in Nonlinear ODEs of ECM Degradation Pathway Network, Theoretical equilibrium considerations explain the failure of the maleic-itaconic copolymer to increase efficiency of fertiliser phosphorus applied to soils, Comparative Analysis of the Interaction between Different Flavonoids and PDIA3, Frontal affinity chromatography: a unique research tool for biospecific interaction that promotes glycobiology, Intercellular signaling by cyclic AMP-containing microparticles, Determination of acid dissociation constants ([pK.sub.a]) of bicyclic thiohydantoin-pyrrolidine compounds in 20% ethanol-water hydroorganic solvent, In vitro selection of a single-stranded DNA molecular recognition element specific for bromacil, Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin, Dissociation-Enhanced Lanthanide Fluorescent Immunoassay. Binding affinity is the strength of the binding interaction between a single biomolecule (e.g. AB It is not intended to provide medical, legal, or any other professional advice. ] Multicellularity led to the evolutio.. Metal–organic complexation in the marine environment, Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA, Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. {\displaystyle K_{a}} Then, the concentration of bound ligands Macromolecules with identical independent binding sites, "Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences", "The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media", "Comparing the Epidermal Growth Factor Interaction with Four Different Cell Lines: Intriguing Effects Imply Strong Dependency of Cellular Context", "Three-dimensional structures of avidin and the avidin-biotin complex", "Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein", "The Ionization Constant of Water over Wide Ranges of Temperature and Density", https://en.wikipedia.org/w/index.php?title=Dissociation_constant&oldid=985540990, Articles with unsourced statements from June 2016, Wikipedia articles needing clarification from June 2016, Pages that use a deprecated format of the chem tags, Creative Commons Attribution-ShareAlike License, This page was last edited on 26 October 2020, at 15:25.

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