In particular, flavonoids present in citrus fruits, such as oranges and grapefruit (95% from flavanones), stand out for their high nutraceutical values. The name “grapefruit” allegedly comes from the fact that grapefruits grow in clusters on trees, like grapes. Tags. The P-glycoprotein inhibition also leads to increased levels of the drug in the serum, due to efflux action of P-glycoprotein (19). Naturally, oranges have been around for a much longer period of time, the first mention of them being in Chinese literature in 314 BC (1). For instance we are assuming that less saturated fats is good for you. An Australian study found that overall, there were 48 studies showing a statistically significant protective effect against cancer of citrus foods with an additional 21 studies showing a non-significant trend to protection. Oranges win in the vitamin category, being also richer in vitamin C, vitamin E, vitamins B1, B2, B3 and B6. However, grapefruits do contain a much higher level of vitamin A. To sum up, oranges are richer in calories, protein and carbohydrates, both fiber and sugar, whereas grapefruits contain more fats. Both fruits contain a similar amount of vitamin B5 and completely lack vitamin D, vitamin K, vitamin B12 and vitamin B9 (folic acid). Dr. Franchesca Vermillion is based in Portland, Ore. and has been writing health-related material for her patients and for public speaking events for more than four years. Oranges, as well as grapefruits contain some amounts of all the essential amino acids. One study demonstrated a significantly greater weight loss in the group consuming grapefruit, grapefruit capsule, and grapefruit juice compared with groups taking placebo. Moreover, naringin also prevents the TNF-α–mediated inflammatory process and tissue damage in liver and vasculature (12). When it comes to minerals, oranges contain more iron, calcium, potassium and copper, while grapefruits are higher in phosphorus. These include lipid transfer proteins, profilin and pectin, as well as limonene, that causes contact dermatitis.. Copyright Policy advertisements are served by third party advertising companies. Both, being strong antioxidants, protect against oxidative damage, inhibit the formation of carcinogens and protect DNA from damage. Grapefruit juice, and sometimes grapefruits, can negatively interact with medications used for high blood pressure, high cholesterol and depression, such as some calcium channel blockers, statins, immunosuppressants, benzodiazepines, beta blockers and other drugs. Diabetic animals treated with orange and grapefruit had a reduced blood glucose concentration when compared to the diabetic control animals. Oranges and grapefruits both classify as low glycemic index foods. Another compound that both fruits are naturally rich in is vitamin C. A significant association has been found between high vitamin C intake and protection against cardiovascular mortality, as well as an inverse relationship with markers of inflammation (5). In most cases, if a person is allergic to one citrus fruit, they are advised to avoid all citrus fruits. The pulp of the most common grapefruits, the ruby red grapefruits, is also usually a darker colour, more pink than orange. Including fruit, especially high in fiber and water, in diets can also play a significant role for people with metabolic syndrome, trying to manage weight gain. A commonly used drug that grapefruit juice has a boosting effect on is called Sildenafil, also known as Viagra. The greatest protection for increased citrus consumption appears to be for oesophageal, oro-phayngeal/laryngeal (mouth, larynx and pharynx) and stomach cancer. Compounds responsible for these effects are said to be vitamin C and flavonoids. People who take medications for high cholesterol, high blood pressure, anxiety or other psychological drugs need to check with a doctor before eating grapefruit in any form. All antioxidants may produce a synergistic effect which may provide strengthening to the B-cells of pancreas to release more insulin (10).

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