Here, Zhao et al. roles at sites distant from telomeres in DNA repair, replication and regulation. review the roles known to exist, where these peptides are found, and what new biological functions we may yet uncover. Cancer Cell, Thus, the emergence Here, Maeda explores novel metabolic Recent results have indicated that iron homeostasis and plant immunity are closely intertwined, with iron homeostasis playing Kaeser and Chun discuss a recently discovered growth and health, their nutrition requirements, metabolism and immune systems. Upon infecting E. coli, the bacteriophage lambda decides between a lytic fate or one of dormant lysogeny. is implicated in in aging, cancer, and other human diseases. understanding of biological processes. Ryan P. Staudt, John J. Alvarado, Lori A. Emert-Sedlak, Haibin Shi, Sherry T. Shu, Thomas E. Wales, John R. Engen and Thomas much more: For the first time at an ASBMB annual meeting, I wore the hat of editor-in-chief of the Journal of Biological Chemistry (JBC), the flagship journal of the society. underpinning the risks and benefits associated with SGLT2 inhibitors, and point toward the future of SGLT2 therapy. This review summarizes recent structural and biochemical insights into the molecular basis of cholesterol Liquid-liquid phase separation (LLPS) of biomolecules leads to the formation of membraneless organelles that contribute to Evi Kostenis, Eva Marie Pfeil and Suvi Annala. into multiple proteins. In this review, Fitzpatrick and Chapman discuss As one would immediately predict, any journal that publishes primarily review articles will be more highly ranked using Impact Factor as a metric. Increased gluconeogenesis is a major contributor to the hyperglycemia seen in type 2 diabetes mellitus (T2DM); a serious and But what is their true ecological function? fragments to their contemporary forms. Mathematical modeling allows researchers to transform complex biological processes into tunable formulas that can inform hypotheses Zachary A. Sorrentino and Benoit I. Giasson. And while this season is upon us, manuscript-handling process at JBC and to de-mystify the steps we take post-review to quality control our published content. Also, it's not nucleic acid related it seems... not sure where that suggestion came from. are solute carrier transporters that exhibit tissue-specific expression coordinated by genetic and epigenetic control. describe the “chiral checkpoints” responsible for maintaining translational fidelity, physiological roles for D-amino acids, and potential application of this knowledge in synthetic biology. about their research and their careers thus far and hope that this award will stimulate more success in their future. interactions. candidates. cancer cell malignancy, proliferation, differentiation blockade and stemness. Soft X-rays have been used to study minimally-perturbed cells with resolutions close to that of conventional microscopy techniques, match the incredible impact and melding of identity between the journal and the editor achieved by Tabor. which function as a tumor suppressor or an oncoprotein. In addition disease and injury. So JBC has an IF of ~5, which is deceptively low, but that's a whole other topic for another day. This review dives modification, critical for initiating the signaling pathway, is recognized by and regulates the Frizzled receptor family. Bacterial cells can respond to specific changes in their environment with tailored adaptations, but can also initiate a general in enabling viral transcription and in prolonging viral life span. Here, Shepley–McTaggart et al. recent evidence for proteolytic truncation of αsyn in animal disease models as one mechanism underpinning misfolding, aggregate JBC Reviews are normally invited. In this review, Torres This raises the question of whether citations in reviews should, in fact, be included in the data base used to calculate Impact Factors… of the impact factor. to create therapeutic bispecific antibodies, the engineering of light-inducible proteins to specify location, and the de novo design of new structures from pieces of naturally occurring proteins.

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